Our research aims to help bridge the gap between structural biology and physiology by pioneering new experimental and computational tools for multi-scale structural biology (atomic to cellular scales). A major focus is the multi-scale structure and function of pancreatic β-cells and the chemical environment of insulin vesicles. Our approach to cell mapping utilizes a combination of multi-modal imaging, biophysical approaches, and integrative modeling metamodeling to relate multi-scale structure to cell function.