Stacey Finley joined the Department of Biomedical Engineering in 2013 as a Gabilan Assistant Professor. Dr. Finley directs the Computational Systems Biology Laboratory (CSBL) at USC. The CSBL constructs mechanistic models of biological processes and utilizes the models to provide quantitative insight into the dynamics and regulation of biological systems. The ultimate goal of this work is to aid in the development of novel therapeutics. Dr. Finley currently applies computational modeling to study angiogenesis, metabolism, and immunotherapy and investigate how these processes are exploited in cancer. To maximize the impact of this work, Dr. Finley’s lab has established collaborations with experimental and clinical researchers, in addition to pursuing their own experimental studies. More information about Dr. Finley’s research is available at: http://csbl.usc.edu
Recent publications include:
Rohrs, J.A.†, Wang, P., Finley, S.D. (2016) “Predictive model of lymphocyte-specific protein tyrosine kinase (LCK) autoregulation”. Cellular and Molecular Bioengineering. In Press. **Invited to appear in the 2016 Young Innovators issue of the journal
Soto-Ortiz, L. and Finley, S.D. (2016) ”A cancer treatment based on synergy between anti-angiogenic and immune cell therapies”. Journal of Theoretical Biology. 394, 197-211.
Finley, S.D., Angelikopoulos, P., Koumoutsakos, P., and Popel, A.S. (2015) “Pharmacokinetics of anti-VEGF agent aflibercept in cancer predicted by data driven, molecular-detailed model”. CPT: Pharmacometrics & Systems Pharmacology. 4(11), 641-649.
Finley, S.D., Chu, L.H., Popel, A.S. (2015) “Computational systems biology approaches to anti-angiogenic cancer therapeutics”. Drug Discovery Today. 20(2), 187-197.
Finley, S.D., Dhar, M. and Popel, A.S. (2013) “Compartment model predicts VEGF secretion and investigates the effects of VEGF Trap in tumor-bearing mice”. Frontiers in Oncology. 3, 196.
Finley, S.D. and Popel, A.S. (2013) “Effect of tumor microenvironment on tumor VEGF during anti- VEGF treatment: systems biology predictions”. Journal of the National Cancer Institute. 105(11), 802-11.
- Frontiers in Engineering Symposium sponsored by the National Academy of Engineering (2016)
- Young Innovator, Cellular and Molecular Bioengineering (2016)
- National Science Foundation CAREER Award (2016)
- Keystone Symposia Fellow (2016)
- Rose Hills Foundation Research Fellowship (2015)
- Emerging Scholar Award from the publication Diverse: Issues in Higher Education (2015)
See Dr. Finley talk about her research: https://vimeo.com/84919582
USC Viterbi Podcast featuring Dr. Finley: